Mechanism of Action

Activates telomerase via interaction with hTERT gene promoter regions, restores pineal gland melatonin secretion, modulates gene expression related to stress response, apoptosis, and antioxidant defense.

Clinical Use

Anti-aging, longevity protocols, sleep optimization. Integrative medicine. Off-label.

Contraindications

CRITICAL: Active malignancy or cancer history — telomerase activation is a hallmark of cancer cells. Cancer safety question with chronic telomerase activation is unresolved.

Evidence Summary

Extensive Russian research (Khavinson group). First independent replication 2025 (Al-Dulaimi, Biogerontology). Cohort mortality data compelling but requires RCT validation.

Key Studies
  • 1.Al-Dulaimi S et al., Biogerontology 2025 — significantly enhanced telomerase activity and increased telomere length. First independent replication outside Russian group. n=5 cell lines, in vitro
  • 2.Khavinson VK et al., 2003 — epithalamin alone: 1.6-1.8x mortality reduction. Combined with thymalin: 2.5x. Annual treatment: 4.1x reduction over 6 years. n=266, cohort study
Evidence Gaps

Limited to Russian research groups until 2025 independent replication. No Western RCTs. Telomerase activation cancer risk unresolved.

Emerging Research

First independent replication outside Russian group (2025). Renewed interest in aging/longevity research.

iRemedy Sourcing Status
AVAILABLE
Available as compounding API — COO documentation available

iRemedy is a 50-state licensed, NABP-accredited wholesale distributor. Peptides supplied with full CoA, DSCSA serialization, and UPS Healthcare cold chain logistics. Wholesale to licensed healthcare facilities and compounding pharmacies only.

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